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Showing posts with label Molecule. Show all posts
Showing posts with label Molecule. Show all posts

Monday, August 10, 2009

Cancer research: Blueberry leaves can help stop Hepatitis C Virus

Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus (HCV). In some cases, those with cirrhosis will go on to develop liver failure or other complications of cirrhosis, including liver cancer. An estimated 270-300 million people worldwide are infected with hepatitis C. Hepatitis C is a strictly human disease. No vaccine against hepatitis C is available. This virus was first isolated in 1989, and hence is a relatively new virus. It is to find vaccines that can reduce the number of people infected by preventing high risk people from getting the virus that research is targeting. There is one research that seems to have found a chemical that can stop the virus (link to article):

Hiroaki Kataoka and colleagues at the University of Miyazaki (U-M) in Japan believed that since HCV is localised in the liver and can take 20 years or more to develop into disease, a dietary supplement might help slow or stop disease progression.
So they screened nearly 300 different agricultural products for potential compounds that suppress HCV replication and uncovered a strong candidate in the leaves of rabbit-eye blueberry (native to the southeastern US). They purified the compound and identified it as proanthocyandin (a polyphenol similar to the beneficial chemicals found in grapes and wine). While proanthocyandin can be harmful, Kataoka and colleagues noted its effective concentration against HCV was 100 times less than the toxic threshold, said a U-M statement.


All such research eventually suceeds when these chemicals succeed in their trials and are rendered fit to be used in humans.

Saturday, July 4, 2009

Drug experiment: Stopping breast cancers

Finding drugs that can beat cancer is a massive, ongoing research. It takes a lot of reseach and medical studies to find suitable molecules that can affect a particular cancer; as a result, when a particular molecule seems to have some promise, it raises a lot of hope and optimism, as in this case for this molecule that seems to have a positive affect on breast cancer (link to article):


A new drug called olaparib may help thousands of women suffering from genetic breast cancer, if results of the first tests on patients are to be believed. The researchers behind the study tested the drug on 54 women with advanced genetic breast cancer, and found that the drug olaparib could stop the growth of tumours and shrink them in more than 40 per cent of cases.
A large number of cases of breast cancer are caused by defects on the BRCA-1 and BRCA-2 genes, which put women at much higher risk of developing aggressive cancers of the breast or ovaries. And, usually, women who test positive for the mutations have their breasts removed as a precaution, because they have an 80 per cent risk of developing breast cancer in their lifetime.


Not every molecule makes it to after trials and studies, but all of them promise hope. The drug could remove the tumor from some of those afflicted; the drug works by acting on a protein that promotes cancer; another positive side effect is by acting only on the cancer cells as opposed to other cancer treatments that have side effects.